Taking the water quality of the Water Diversion to Jiaodong Area Project as the research object, this paper adopts the comprehensive pollution index method to analyze the current water quality status as well as the temporal and spatial variation trends of water quality in the project. The results show that the current water quality of the Project meets the standard; the water quality in the downstream is slightly better than that in the upstream. The annual water quality presents an overall qualified status with inter-annual differences. The findings can provide a reference for water quality management of the Project.